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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G/A

Under the Securities Exchange Act of 1934

(Amendment No. 4)

GRITSTONE BIO, INC.

(Name of Issuer)

Common Stock, $0.0001 par value

(Title of Class of Securities)

39868T105

(CUSIP Number)

September 17, 2021

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 39868T105

1	Name of Reporting Person Redmile Group, LLC
2	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ¨ (b) ¨
3	SEC Use Only
4	Citizenship or Place of Organization Delaware
number of shares beneficially owned by each reporting person with		5	Sole Voting Power 0
		6	Shared Voting Power 5,729,916 ⁽¹⁾
		7	Sole Dispositive Power 0
		8	Shared Dispositive Power 5,729,916 ⁽¹⁾
9	Aggregate Amount Beneficially Owned by Each Reporting Person 5,729,916 ⁽¹⁾
10	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨
11	Percent of Class Represented by Amount in Row (9) 9.9% ⁽²⁾
12	Type of Reporting Person (See Instructions) IA, OO

⁽¹⁾ Redmile Group, LLC’s beneficial ownership of the Issuer’s common stock (“Common Stock”) is comprised of 2,821,085 shares of Common Stock owned by certain private investment vehicles and/or separately managed accounts managed by Redmile Group, LLC, which shares of Common Stock may be deemed beneficially owned by Redmile Group, LLC as investment manager of such private investment vehicles and/or separately managed accounts. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile Group, LLC. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except to the extent of its or his pecuniary interest in such shares, if any. Subject to the Beneficial Ownership Blocker (as defined below), Redmile Group, LLC may also be deemed to beneficially own 15,060,000 shares of Common Stock issuable upon exercise of certain Pre-Funded Warrants to Purchase Common Stock (the “Warrants”). Pursuant to the terms of the Warrants, a holder of a Warrant does not have the right to exercise any portion of the Warrant held by such holder, and any such exercise shall be void ab initio, to the extent (but only to the extent) that after giving effect to such issuance after exercise, the holder (together with the holder’s affiliates, and any other persons acting as a group together with the holder or any of the holder’s affiliates), would beneficially own in excess of 9.99% (the “Beneficial Ownership Limitation”) of the number of shares of Common Stock outstanding immediately after giving effect to the issuance of shares of Common Stock issued upon exercise of the Warrant (the “Beneficial Ownership Blocker”). The Beneficial Ownership Limitation may be changed at a holder’s election upon 61 days’ notice to the Issuer. The 5,729,916 shares of Common Stock reported as beneficially owned by Redmile Group, LLC in this Schedule 13G represents 9.99% of the outstanding shares of Common Stock (calculated in accordance with footnote (2) below).

⁽²⁾ Percentage based on 57,356,524 shares of Common Stock outstanding, which is the sum of (i) 49,447,693 shares of Common Stock outstanding as of July 30, 2021 as reported by the Issuer in its quarterly report on Form 10-Q for the quarterly period ended June 30, 2021 filed with the SEC on August 5, 2021 (the “Form 10-Q”); plus (ii) 5,000,000 shares of Common Stock that were sold on September 17, 2021 as described in the Issuer’s Current Report on Form 8-K filed with the SEC on September 17, 2021 (the “Form 8-K”); plus (iii) 2,908,831 shares of Common Stock issuable upon exercise of certain of the Warrants, which, due to the Beneficial Ownership Limitation, is the maximum number of shares that could be issued upon exercise of the Warrants at this time.

CUSIP No. 39868T105

1	Name of Reporting Person Jeremy C. Green
2	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ¨ (b) ¨
3	SEC Use Only
4	Citizenship or Place of Organization United Kingdom
number of shares beneficially owned by each reporting person with		5	Sole Voting Power 0
		6	Shared Voting Power 5,729,916 ⁽³⁾
		7	Sole Dispositive Power 0
		8	Shared Dispositive Power 5,729,916 ⁽³⁾
9	Aggregate Amount Beneficially Owned by Each Reporting Person 5,729,916 ⁽³⁾
10	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨
11	Percent of Class Represented by Amount in Row (9) 9.9%⁽⁴⁾
12	Type of Reporting Person (See Instructions) IN, HC

⁽³⁾ Jeremy C. Green’s beneficial ownership of Common Stock is comprised of 2,821,085 shares of Common Stock owned by certain private investment vehicles and/or separately managed accounts managed by Redmile Group, LLC, which shares of Common Stock may be deemed beneficially owned by Redmile Group, LLC as investment manager of such private investment vehicles and/or separately managed accounts. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile Group, LLC. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except to the extent of its or his pecuniary interest in such shares, if any. Subject to the Beneficial Ownership Blocker, Mr. Green may also be deemed to beneficially own 15,060,000 shares of Common Stock issuable upon exercise of the Warrants. Pursuant to the terms of the Warrants, the Issuer may not effect any exercise of any Warrant, and a holder of a Warrant does not have the right to exercise any portion of the Warrant held by such holder, to the extent that the Beneficial Ownership Blocker applies. The 5,729,916 shares of Common Stock reported as beneficially owned by Redmile Group, LLC in this Schedule 13G represents 9.99% of the outstanding shares of Common Stock (calculated in accordance with footnote (4) below).

⁽⁴⁾ Percentage based on 57,356,524 shares of Common Stock outstanding, which is the sum of (i) 49,447,693 shares of Common Stock outstanding as of July 30, 2021 as reported by the Issuer in the Form 10-Q; plus (ii) 5,000,000 shares of Common Stock that were sold on September 17, 2021 as described in the Form 8-K; plus (iii) 2,908,831 shares of Common Stock issuable upon exercise of certain of the Warrants, which, due to the Beneficial Ownership Limitation, is the maximum number of shares that could be issued upon exercise of the Warrants at this time.

CUSIP No. 39868T105

1	Name of Reporting Person Redmile Strategic Master Fund, LP
2	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ¨ (b) ¨
3	SEC Use Only
4	Citizenship or Place of Organization Cayman Islands
number of shares beneficially owned by each reporting person with		5	Sole Voting Power 0
		6	Shared Voting Power 3,563,094 ⁽⁵⁾
		7	Sole Dispositive Power 0
		8	Shared Dispositive Power 3,563,094 ⁽⁵⁾
9	Aggregate Amount Beneficially Owned by Each Reporting Person 3,563,094 ⁽⁵⁾
10	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨
11	Percent of Class Represented by Amount in Row (9) 6.2% ⁽⁶⁾
12	Type of Reporting Person (See Instructions) PN, FI

⁽⁵⁾ Redmile Strategic Master Fund, LP’s beneficial ownership of the Issuer’s Common Stock is comprised of 708,494 shares of Common Stock and 2,854,600 shares of Common Stock issuable upon exercise of the Warrant directly held by Redmile Strategic Master Fund, LP.

⁽⁶⁾ Percentage based on 57,302,293 shares of Common Stock outstanding, which is the sum of (i) 49,447,693 shares of Common Stock outstanding as of July 30, 2021 as reported by the Issuer in the Form 10-Q, plus (ii) 5,000,000 shares of Common Stock that were sold on September 17, 2021 as described in the Form 8-K; plus (iii) 2,854,600 shares of Common Stock issuable upon exercise of the Warrants directly held by Redmile Strategic Master Fund, LP (the “Strategic Master Warrants”).

CUSIP No. 39868T105

1	Name of Reporting Person Redmile Capital Offshore Master Fund, Ltd.
2	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ¨ (b) ¨
3	SEC Use Only
4	Citizenship or Place of Organization Cayman Islands
number of shares beneficially owned by each reporting person with		5	Sole Voting Power 0
		6	Shared Voting Power 3,029,137 ⁽⁷⁾
		7	Sole Dispositive Power 0
		8	Shared Dispositive Power 3,029,137 ⁽⁷⁾
9	Aggregate Amount Beneficially Owned by Each Reporting Person 3,029,137 ⁽⁷⁾
10	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨
11	Percent of Class Represented by Amount in Row (9) 5.3% ⁽⁸⁾
12	Type of Reporting Person (See Instructions) CO, FI

⁽⁷⁾ Redmile Capital Offshore Master Fund, Ltd.’s beneficial ownership of the Issuer’s Common Stock is comprised of 120,306 shares of Common Stock and, subject to the Beneficial Ownership Blocker, 3,234,900 shares of Common Stock issuable upon exercise of the Warrants directly held Redmile Capital Offshore Master Fund, Ltd. Pursuant to the terms of the Warrants, the Issuer may not effect any exercise of any Warrant, and a holder of a Warrant does not have the right to exercise any portion of the Warrant held by such holder, to the extent that the Beneficial Ownership Blocker applies. The 2,908,831 shares of Common Stock reported as beneficially owned by Redmile Capital Offshore Master Fund, Ltd. in this Schedule 13G represents the maximum number of shares that could be issued to Redmile Capital Offshore Master Fund, Ltd. upon exercise of its Warrant (calculated in accordance with footnote (8) below) due to the Beneficial Ownership Limitation.

⁽⁸⁾ Percentage based on 57,356,524 shares of Common Stock outstanding, which is the sum of (i) 49,447,693 shares of Common Stock outstanding as of July 30, 2021 as reported by the Issuer in the Form 10-Q, plus (ii) 5,000,000 shares of Common Stock that were sold on September 17, 2021 as described in the Form 8-K; plus (iii) 2,908,831 shares of Common Stock issuable upon exercise of Warrants directly held by Redmile Capital Offshore Master Fund, Ltd. (the “Offshore Master Warrants”).

CUSIP No. 39868T105

1	Name of Reporting Person RedCo I, L.P.
2	Check the Appropriate Box if a Member of a Group (See Instructions) (a) ¨ (b) ¨
3	SEC Use Only
4	Citizenship or Place of Organization Delaware
number of shares beneficially owned by each reporting person with		5	Sole Voting Power 0
		6	Shared Voting Power 2,908,831 ⁽⁹⁾
		7	Sole Dispositive Power 0
		8	Shared Dispositive Power 2,908,831 ⁽⁹⁾
9	Aggregate Amount Beneficially Owned by Each Reporting Person 2,908,831 ⁽⁹⁾
10	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨
11	Percent of Class Represented by Amount in Row (9) 5.1% ⁽¹⁰⁾
12	Type of Reporting Person (See Instructions) PN

⁽⁹⁾ Subject to the Beneficial Ownership Blocker, RedCo I, L.P. beneficially owns 4,009,399 shares of Common Stock issuable upon exercise of the Warrant directly held by RedCo I, L.P. Pursuant to the terms of the Warrants, the Issuer may not effect any exercise of any Warrant, and a holder of a Warrant does not have the right to exercise any portion of the Warrant held by such holder, to the extent that the Beneficial Ownership Blocker applies. The 2,908,831 shares of Common Stock reported as beneficially owned by RedCo I, L.P. in this Schedule 13G represents the maximum number of shares that could be issued to RedCo I, L.P. upon exercise of its Warrant (calculated in accordance with footnote (10) due to the Beneficial Ownership Limitation.

⁽¹⁰⁾ Percentage based on 57,356,524 shares of Common Stock outstanding, which is the sum of (i) 49,447,693 shares of Common Stock outstanding as of July 30, 2021 as reported by the Issuer in the Form 10-Q, plus (ii) 5,000,000 shares of Common Stock that were sold on September 17, 2021 as described in the Form 8-K; plus (iii) 2,908,831 shares of Common Stock issuable upon exercise of certain of the Warrants directly held by RedCo I, L.P. (the “RedCo Warrants”) which, due to the Beneficial Ownership Limitation, is the maximum number of shares that could be issued upon exercise of the Warrants at this time.

Item 1.

(a)

Name of Issuer

Gritstone bio, Inc.

(b)

Address of Issuer’s Principal Executive Offices

5959 Horton Street, Suite 300

Emeryville, California 94608

Item 2.

(a)

Name of Each Person Filing (each, a “Reporting Person”)

Redmile Group, LLC
Jeremy C. Green

Redmile Strategic Master Fund, LP

Redmile Capital Offshore Master Fund, Ltd.

RedCo I, L.P.

(b)

Address of Principal Business office of each Reporting Person is:

One Letterman Drive
Building D, Suite D3-300
The Presidio of San Francisco
San Francisco, California 94129

(c)

Citizenship

Redmile Group, LLC: Delaware
Jeremy C. Green: United Kingdom

Redmile Strategic Master Fund, LP: Cayman Islands

Redmile Capital Offshore Master Fund, Ltd.: Cayman Islands

RedCo I, L.P.: Delaware

(d)

Title of Class of Securities

Common Stock, $0.0001 par value

(e)

CUSIP Number

39868T105

Item 3.

If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

(a)

Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);

(b)

Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);

(c)

Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);

(d)

Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C 80a-8);

(e)

An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);

(f)

An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);

(g)

A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);

(h)

A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

(i)

A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j)

A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J);

(k)

Group, in accordance with § 240.13d-1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution: _______

Item 4.

Ownership.

(a)

Amount beneficially owned:

Redmile Group, LLC – 5,729,916*
Jeremy C. Green – 5,729,916*

Redmile Strategic Master Fund, LP – 3,563,094 **

Redmile Capital Offshore Master Fund, Ltd. – 3,029,137 ***

RedCo I, L.P. – 2,908,831 ****

(b)

Percent of class:

Redmile Group, LLC – 9.9%*
Jeremy C. Green – 9.9%*

Redmile Strategic Master Fund, LP – 6.2% **

Redmile Capital Offshore Master Fund, Ltd. – 5.3% ***

RedCo I, L.P. – 5.1% ****

(c)

Number of shares as to which Redmile Group, LLC has:

(i)

Sole power to vote or to direct the vote: 0

(ii)

Shared power to vote or to direct the vote: 5,729,916*

(iii)

Sole power to dispose or to direct the disposition of: 0

(iv)

Shared power to dispose or to direct the disposition of: 5,729,916*

Number of shares as to which Jeremy C. Green has:

(i)

Sole power to vote or to direct the vote: 0

(ii)

Shared power to vote or to direct the vote: 5,729,916*

(iii)

Sole power to dispose or to direct the disposition of: 0

(iv)

Shared power to dispose or to direct the disposition of: 5,729,916*

Number of shares as to which Redmile Strategic Master Fund, LP has:

(i)

Sole power to vote or to direct the vote: 0

(ii)

Shared power to vote or to direct the vote: 3,563,094 **

(iii)

Sole power to dispose or to direct the disposition of: 0

(iv)

Shared power to dispose or to direct the disposition of: 3,563,094 **

Number of shares as to which Redmile Capital Offshore Master Fund, Ltd. has:

(i)

Sole power to vote or to direct the vote: 0

(ii)

Shared power to vote or to direct the vote: 3,029,137 ***

(iii)

Sole power to dispose or to direct the disposition of: 0

(iv)

Shared power to dispose or to direct the disposition of: 3,029,137 ***

Number of shares as to which RedCo I, L.P. has:

(i)

Sole power to vote or to direct the vote: 0

(ii)

Shared power to vote or to direct the vote: 2,908,831 ****

(iii)

Sole power to dispose or to direct the disposition of: 0

(iv)

Shared power to dispose or to direct the disposition of: 2,908,831 ****

Redmile Group, LLC’s and Jeremy C. Green’s beneficial ownership of the Issuer’s Common Stock is comprised of 2,821,085 shares of Common Stock owned by certain private investment vehicles and/or separately managed accounts managed by Redmile Group, LLC, which shares of Common Stock may be deemed beneficially owned by Redmile Group, LLC as investment manager of such private investment vehicles and/or separately managed accounts. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile Group, LLC. Redmile Group, LLC and Mr. Green each disclaim beneficial ownership of these shares, except to the extent of its or his pecuniary interest in such shares, if any. Subject to the Beneficial Ownership Blocker, Redmile Group, LLC and Mr. Green may also be deemed to beneficially own 15,060,000 shares of Common Stock issuable upon exercise of the Warrants. Pursuant to the terms of the Warrants, a holder of a Warrant does not have the right to exercise any portion of the Warrant held by such holder, and such exercise will be void ab initio, if the Beneficial Ownership Blocker applies. The 5,729,916 shares of Common Stock reported as beneficially owned by Redmile Group, LLC and Mr. Green in this Schedule 13G represents 9.99% of the outstanding shares of Common Stock.

Percentage based on 57,356,524 shares of Common Stock outstanding, which is the sum of (i) 49,447,693 shares of Common Stock outstanding as of July 30, 2021 as reported by the Issuer in the Form 10-Q; plus (ii) 5,000,000 shares of Common Stock that were sold on September 17, 2021 as described in the Form 8-K; plus (iii) 2,908,831 shares of Common Stock issuable upon exercise of certain of the Warrants, which, due to the Beneficial Ownership Limitation, is the maximum number of shares that could be issued upon exercise of the Warrants at this time.

Redmile Strategic Master Fund, LP’s beneficial ownership of the Issuer’s Common Stock is comprised of 708,494 shares of Common Stock and 2,854,600 shares of common stock issuable upon the exercise of Warrants directly held by Redmile Strategic Master Fund, LP.

Percentage based on 57,302,293 shares of Common Stock outstanding, which is the sum of (i) 49,447,693 shares of Common Stock outstanding as of July 30, 2021 as reported by the Issuer in the Form 10-Q, plus (ii) 5,000,000 shares of Common Stock that were sold on September 17, 2021 as described in the Form 8-K; plus (iii) 2,854,600 shares of Common Stock issuable upon exercise of the Warrants directly held by Redmile Strategic Master Fund, LP.

***

Redmile Capital Offshore Master Fund, Ltd.’s beneficial ownership of the Issuer’s Common Stock is comprised of 120,306 shares of Common Stock and 2,908,831 shares of common stock issuable upon the exercise of Warrants directly held by Redmile Capital Offshore Master Fund, Ltd.

Percentage based on 57,356,524 shares of Common Stock outstanding, which is the sum of (i) 49,447,693 shares of Common Stock outstanding as of July 30, 2021 as reported by the Issuer in the Form 10-Q, plus (ii) 5,000,000 shares of Common Stock that were sold on September 17, 2021 as described in the Form 8-K; plus (iii) 2,908,831 shares of Common Stock issuable upon exercise of Warrants directly held by Redmile Capital Offshore Master Fund, Ltd.

****

Subject to the Beneficial Ownership Blocker, RedCo I, L.P. beneficially owns 4,009,399 shares of Common Stock issuable upon exercise of the Warrant directly held by RedCo I, L.P. The 2,908,831 shares of Common Stock reported as beneficially owned by RedCo I, L.P. in this Schedule 13G represents the maximum number of shares that could be issued to RedCo I, L.P. upon exercise of its Warrant at this time due to the Beneficial Ownership Limitation.

Percentage based on 52,184,892 shares of Common Stock outstanding, which is the sum of (i) 49,447,693 shares of Common Stock outstanding as of July 30, 2021 as reported by the Issuer in the Form 10-Q, plus (ii) 5,000,000 shares of Common Stock that were sold on September 17, 2021 as described in the Form 8-K; plus (iii) 2,908,831 shares of Common Stock issuable upon exercise of certain of the Warrants directly held by RedCo I, L.P. which, due to the Beneficial Ownership Limitation, is the maximum number of shares that could be issued upon exercise of the Warrants at this time.

Item 5.

Ownership of Five Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than 5 percent of the class of securities, check the following ¨

Item 6.

Ownership of More than Five Percent on Behalf of Another Person.

N/A.

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.

See the response to Item 4.

Item 8.

Identification and Classification of Members of the Group.

N/A

Item 9.

Notice of Dissolution of Group.

N/A

Item 10.

Certifications.

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: September 27, 2021

Redmile Group, LLC

By:		/s/ Jeremy C. Green
		Name: Jeremy C. Green Title: Managing Member

		/s/ Jeremy C. Green
		Jeremy C. Green

Redmile Strategic Master Fund, LP By: Redmile Group, LLC, its investment manager

By:		/s/ Jeremy C. Green
		Name: Jeremy C. Green Title: Authorized Person
Redmile Capital Offshore Master Fund, Ltd. By: Redmile Group, LLC, its investment manager

By:		/s/ Jeremy C. Green
		Name: Jeremy C. Green Title: Authorized Person
RedCo I, L.P. By: RedCo I (GP), LLC, its general partner

By:		/s/ Jeremy C. Green
		Name: Jeremy C. Green Title: Authorized Person

Exhibit 99.1

Joint Filing Agreement

In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), the undersigned hereby agree to the joint filing on behalf of each of them of a Statement on Schedule 13G (including any and all amendments thereto, the “Schedule 13G”) relating to the Common Stock, $0.0001 par value per share, of Gritstone bio, Inc., which may be deemed necessary pursuant to Regulation 13D or 13G promulgated under the Exchange Act.

The undersigned further agree that each party hereto is responsible for the timely filing of the Schedule 13G, and for the accuracy and completeness of the information concerning such party contained therein; provided, however, that no party is responsible for the accuracy or completeness of the information concerning any other party, unless such party knows or has a reason to believe that such information is inaccurate.

It is understood and agreed that a copy of this Joint Filing Agreement shall be attached as an exhibit to the Schedule 13G, filed on behalf of each of the parties hereto.

IN WITNESS WHEREOF, each of the undersigned has executed this Joint Filing Agreement as of the 27th day of September, 2021.

REDMILE GROUP, LLC

/s/ Jeremy C. Green

Name: Jeremy C. Green

Title: Managing Member

/s/ Jeremy C. Green

JEREMY C. Green

Redmile Strategic Master Fund, LP

By: Redmile Group, LLC, its investment manager

/s/ Jeremy C. Green

Name: Jeremy C. Green

Title: Authorized Person

Redmile Capital Offshore Master Fund, Ltd.

By: Redmile Group, LLC, its investment manager

/s/ Jeremy C. Green

Name: Jeremy C. Green

Title: Authorized Person

RedCO I, L.P.

By: RedCo I (GP), LLC, its general partner

/s/ Jeremy C. Green

Name: Jeremy C. Green

Title: Authorized Person