September 14, 2018 Andrew Allen, M.D., Ph.D. President and Chief Executive Officer Gritstone Oncology, Inc. 5858 Horton Street, Suite 210 Emeryville, CA 94608 Re: Gritstone Oncology, Inc. Registration Statement on Form S-1 Response dated September 6, 2018 File No. 333-226976 Dear Dr. Allen: We have reviewed your September 6, 2018 response to our comment letter and have the following comment. Please respond to this letter by amending your registration statement and providing the requested information. If you do not believe our comment applies to your facts and circumstances or do not believe an amendment is appropriate, please tell us why in your response. After reviewing any amendment to your registration statement and the information you provide in response to this comment, we may have additional comments. Unless we note otherwise, our references to prior comments are to comments in our August 30, 2018 letter. Response dated September 6, 2018 Strategic Collaboration with bluebird bio, page 121 1. We note your response to our prior comment 1. Please revise the disclosure regarding this agreement on page 121 of your Registration Statement on Form S-1 to identify the royalty term. Andrew Allen, M.D., Ph.D. Gritstone Oncology, Inc. September 14, 2018 Page 2 You may contact Rolf Sundwall at 202-551-3105 or Jim B. Rosenberg at 202-551-3679 if you have questions regarding comments on the financial statements and related matters. Please contact Ada D. Sarmento at 202-551-3798 or Mary Beth Breslin at 202-551-3625 with any other questions. Sincerely, FirstName LastNameAndrew Allen, M.D., Ph.D. Division of Corporation Finance Comapany NameGritstone Oncology, Inc. Office of Healthcare & Insurance September 14, 2018 Page 2 cc: Brian J. Cuneo, Esq. FirstName LastName