United States securities and exchange commission logo October 25, 2021 Andrew Allen President and Chief Executive Officer Gritstone bio, Inc. 5959 Horton Street, Suite 300 Emeryville, California 94608 Re: Gritstone bio, Inc. Registration Statement on Form S-3 Filed October 15, 2021 File No. 333-260292 Dear Dr. Allen: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Jordan Nimitz at 202-551-6001 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Brian Cuneo, Esq.