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240.13d-102 Schedule 13G - Information to be included in statements filed
pursuant to 240.13d-1(b), (c), and (d) and amendments thereto
filed pursuant to 240.13d-2.

Securities and Exchange Commission, Washington, D.C. 20549

Schedule 13G

Under the Securities Exchange Act of 1934

(Amendment No. 1)*

(Name of Issuer)

Gritstone bio, Inc.

(Title of Class of Securities)

Common Stock, par value $0.0001 per share

(CUSIP Number)

39868T105

(Date of Event Which Requires Filing of this Statement)

December 31, 2022

Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

[  ] Rule 13d-1(b)

[ x ] Rule 13d-1(c)

[  ] Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be
deemed to be “filed” for the purpose of Section 18 of the Securities Exchange
Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the
Act but shall be subject to all other provisions of the Act (however, see
the Notes).


CUSIP No. 39868T105
(1) Names of reporting persons    Point72 Asset Management, L.P.
 
(2) Check the appropriate box if a member of a group
(a)
(see instructions)
(b)X
(3) SEC use only
 
(4) Citizenship or place of organization Delaware
 
Number of shares beneficially owned by each reporting person with:
 
(5) Sole voting power                  0
 
(6) Shared voting power              7,679,867
 
(7) Sole dispositive power           0
 
(8) Shared dispositive power       7,679,867
 
(9) Aggregate amount beneficially owned by each reporting person
7,679,867
 
(10) Check if the aggregate amount in Row (9) excludes certain shares
(see instructions)
 
(11) Percent of class represented by amount in Row (9) 9.2%
 
(12) Type of reporting person (see instructions) PN
 



CUSIP No. 39868T105
(1) Names of reporting persons    Point72 Capital Advisors, Inc.
 
(2) Check the appropriate box if a member of a group
(a)
(see instructions)
(b)X
(3) SEC use only
 
(4) Citizenship or place of organization Delaware
 
Number of shares beneficially owned by each reporting person with:
 
(5) Sole voting power                  0
 
(6) Shared voting power              7,679,867
 
(7) Sole dispositive power           0
 
(8) Shared dispositive power       7,679,867
 
(9) Aggregate amount beneficially owned by each reporting person
7,679,867
 
(10) Check if the aggregate amount in Row (9) excludes certain shares
(see instructions)
 
(11) Percent of class represented by amount in Row (9) 9.2%
 
(12) Type of reporting person (see instructions) CO
 



CUSIP No. 39868T105
(1) Names of reporting persons    Cubist Systematic Strategies, LLC
 
(2) Check the appropriate box if a member of a group
(a)
(see instructions)
(b)X
(3) SEC use only
 
(4) Citizenship or place of organization Delaware
 
Number of shares beneficially owned by each reporting person with:
 
(5) Sole voting power                  0
 
(6) Shared voting power              22,964
 
(7) Sole dispositive power           0
 
(8) Shared dispositive power       22,964
 
(9) Aggregate amount beneficially owned by each reporting person
22,964
 
(10) Check if the aggregate amount in Row (9) excludes certain shares
(see instructions)
 
(11) Percent of class represented by amount in Row (9) <0.1%
 
(12) Type of reporting person (see instructions) OO
 



CUSIP No. 39868T105
(1) Names of reporting persons    Steven A. Cohen
 
(2) Check the appropriate box if a member of a group
(a)
(see instructions)
(b)X
(3) SEC use only
 
(4) Citizenship or place of organization United States
 
Number of shares beneficially owned by each reporting person with:
 
(5) Sole voting power                  0
 
(6) Shared voting power              7,702,831
 
(7) Sole dispositive power           0
 
(8) Shared dispositive power       7,702,831
 
(9) Aggregate amount beneficially owned by each reporting person
7,702,831
 
(10) Check if the aggregate amount in Row (9) excludes certain shares
(see instructions)
 
(11) Percent of class represented by amount in Row (9) 9.2%
 
(12) Type of reporting person (see instructions) IN
 


Item 1(a) Name of issuer:

Gritstone bio, Inc.

Item 1(b) Address of issuer's principal executive offices:

5959 Horton Street, Suite 300, Emeryville, California 94608

2(a) Name of person filing:

This statement is filed by: (i) Point72 Asset Management, L.P. (“Point72 Asset Management”)
with respect to shares of common stock, par value $0.0001 per share (“Shares”), of the Issuer
held by Point72 Associates, LLC, an investment fund it manages (“Point72 Associates”); (ii)
Point72 Capital Advisors, Inc. (“Point72 Capital Advisors Inc.”) with respect to Shares held by
Point72 Associates; (iii) Cubist Systematic Strategies, LLC (“Cubist Systematic Strategies”)
with respect to Shares held by an investment fund it manages; and (iv) Steven A. Cohen
(“Mr. Cohen”) with respect to Shares beneficially owned by Point72 Asset Management,
Point72 Capital Advisors Inc., and Cubist Systematic Strategies.

2(b) Address or principal business office or, if none, residence:

The address of the principal business office of (i) Point72 Asset Management, Point72 Capital
Advisors Inc., and Mr. Cohen is 72 Cummings Point Road, Stamford, CT 06902; and (ii) Cubist
Systematic Strategies is 55 Hudson Yards, New York, NY 10001.

2(c) Citizenship:

Point72 Asset Management is a Delaware limited partnership. Point72 Capital Advisors Inc. is a
Delaware corporation. Cubist Systematic Strategies is a Delaware limited liability company.
Mr. Cohen is a United States citizen.

2(d) Title of class of securities:

Common Stock, par value $0.0001 per share

2(e) CUSIP Number:

39868T105

Item 3.

Not applicable


Item 4. Ownership

The information required by Items 4(a) – (c) is set forth in Rows (5) – (11) of the cover page for
each Reporting Person hereto and is incorporated herein by reference for each Reporting Person.
Such information is as of the close of business on December 31, 2022.

Point72 Asset Management, Point72 Capital Advisors Inc., Cubist Systematic Strategies, and
Mr. Cohen own directly no Shares. Pursuant to an investment management agreement, Point72
Asset Management maintains investment and voting power with respect to the securities held by
Point72 Associates. Point72 Capital Advisors Inc. is the general partner of Point72 Asset
Management. Pursuant to an investment management agreement, Cubist Systematic Strategies
maintains investment and voting power with respect to the securities held by an investment fund
it manages. Mr. Cohen controls each of Point72 Asset Management, Point72 Capital Advisors
Inc., and Cubist Systematic Strategies.  The filing of this statement should not be construed as an
admission that any of the foregoing persons or any reporting person is, for the purposes of
Section 13 of the Act, the beneficial owner of the Shares reported herein.

Item 5. Ownership of 5 Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof the reporting person has
ceased to be the beneficial owner of more than 5 percent of the class of securities, check the
following [  ].

Item 6.  Ownership of More than 5 Percent on Behalf of Another Person.

Point72 Associates has the right to receive or the power to direct the receipt of dividends from,
or the proceeds from the sale of, the Shares reported herein.

Item 7.  Identification and Classification of the Subsidiary Which Acquired
the Security Being Reporting on by the Parent Holding Company or Control
Person.

Not applicable

Item 8. Identification and Classification of Members of the Group

Not applicable

Item 9.  Notice of Dissolution of Group.

Not applicable

Item 10. Certifications

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not
acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer
of the securities and were not acquired and are not held in connection with or as a participant in any transaction
having that purpose or effect.

Signature.  After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.


Dated: February 14, 2023


POINT72 ASSET MANAGEMENT, L.P.

By: /s/ Jason M. Colombo
Name: Jason M. Colombo
Title: Authorized Person


POINT72 CAPITAL ADVISORS, INC.

By: /s/ Jason M. Colombo
Name: Jason M. Colombo
Title: Authorized Person


CUBIST SYSTEMATIC STRATEGIES, LLC

By: /s/ Jason M. Colombo
Name: Jason M. Colombo
Title: Authorized Person


STEVEN A. COHEN
By: /s/ Jason M. Colombo
Name: Jason M. Colombo
Title: Authorized Person