Gritstone bio and the National Cancer Institute (NCI) Establish a Clinical Trial Agreement to Evaluate a Neoantigen Cell Therapy-Vaccine Combination
“We are privileged to establish this collaboration with NCI and
Under the terms of the agreement, NCI will identify patients with metastatic cancer that are eligible for adoptive cell transfer based on the presence of a G12V or G12D KRAS mutation (KRASmut). Gritstone will provide the SLATE-KRAS vaccine as requested by NCI for the trial.
“The use of neoantigen vaccines to enhance the potency of neoantigen-directed T cell therapy is an attractive concept with supportive pre-clinical data,” said
An “off the shelf” neoantigen vaccine candidate, SLATE-KRAS demonstrated early evidence of efficacy as defined by molecular response in immune checkpoint blockade (ICB)-resistant/refractory subjects in the Phase 2 portion of an ongoing Phase 1/2 study (NCT03953235). Based on the results to date from the Phase 1/2 study, Gritstone has elected to initiate a separate, randomized Phase 2 study evaluating SLATE against a KRASmut-driven tumor type. Gritstone expects to initiate this separate, randomized study in the second half of 2023.
About Gritstone bio
Gritstone is working to create the world’s most potent vaccines. We leverage our innovative vectors and payloads to train multiple arms of the immune system to attack critical disease targets and have programs in viral diseases and solid tumors. Independently and with our partners, we are advancing a portfolio of product candidates with the aim of improving patient outcomes and eliminating disease. www.gritstonebio.com
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Director, Investor Relations & Corporate Communications