Gritstone Presentations at AACR Further Support Expertise in Neoantigen Vaccine Design and Delivery
-- Translational immunology data and cassette design capabilities enabled development of an optimized, KRAS-specific version of “off-the-shelf” vaccine candidate now in Phase 2 (SLATE-KRAS) --
-- GRANITE data (individualized neoantigen-based therapeutic vaccine program) support circulating tumor DNA (ctDNA) response as a predictor of overall survival in metastatic colorectal cancer --
-- Detailed analysis from oncology programs supports potency and dose sparing potential of self-amplifying mRNA (samRNA) --
“The collective data we presented at AACR reinforce our expertise in designing and delivering potent vaccines, and support the optimization of antigen cassette design, dose and vaccine regimen as key tools to induce differentiated immune response,” said
Oral Presentation: Optimization of shared neoantigen vaccine design to increase vaccine potency: From bench to bedside and back
Presenter: Christine D Palmer, PhD
- SLATE v1* was well-tolerated and demonstrated a favorable safety profile in all subjects dosed (n=26). Greatest activity was seen in six (6) NSCLC patients with KRASmut G12C mutations.
- Gritstone subsequently developed a second, optimized product candidate (SLATE-KRAS) that exclusively includes epitopes from mutated KRAS.
- SLATE-KRAS is being evaluated in the Phase 2 portion of a Phase 1/2 trial (NCT03953235), with initial data expected in the second half of 2022.
*SLATE v1 was administered in combination with Opdivo® (nivolumab) and subcutaneous anti-CTLA-4 antibody Yervoy® (ipilimumab). Opdivo® and Yervoy® are trademarks of Bristol-Myers Squibb Company.
Additional presentations at AACR further elucidated the correlation between patient survival and circulating tumor DNA (ctDNA) in solid tumors (relevant to the company’s individualized vaccine program, GRANITE) and detailed a dose-response analysis, the results of which further support the dose-sparing potential of the company’s novel vector which is it utilizing in both oncology and infectious disease, self-amplifying mRNA (samRNA).
Poster Presentation: Comprehensive ctDNA monitoring provides early signal of clinical benefit with a novel personalized neoantigen directed immunotherapy for late-stage cancer patients
- Majority of neoantigens are retained in tumor even after patient receives treatment
- ctDNA longitudinal monitoring enables real-time assessment of response/resistance
- Molecular response elicited in four (4) of nine (9) treated subjects that correlated with prolonged progression-free survival and overall survival support clinical benefit of GRANITE in patients with advanced MSS-CRC
Poster Presentation: Lower doses of self-amplifying mRNA drive superior neoantigen-specific CD8+ T cell responses in cancer patients versus high doses
- samRNA demonstrated a favorable safety profile at all 3 dose levels, with no evidence of increasing reactogenicity with sequential doses
- Lower dose samRNA (30 μg) increased T cell and humoral responses following a
ChAdprime, while higher doses of samRNA (300 μg) only maintained initial response to ChAd
- Dose dependent induction of IFN⍺ in cancer patients and nonhuman primates suggest inhibitory impact of early innate immune activation
To view Gritstone’s AACR presentations, visit ir.gritstonebio.com/investors/events.
Gritstone’s neoantigen-based immunotherapies are engineered to elicit a significant T-cell response (particularly CD8+ cytotoxic T cells) against mutation-derived tumor-specific neoantigens, or TSNA, that are identified by the company using its proprietary Gritstone EDGE™ artificial intelligence platform and tumor HLA peptide sequencing. SLATE, Gritstone’s “off-the-shelf” immunotherapy program, uses a priming adenoviral vector and self-amplifying mRNA vector to deliver a cassette of shared TSNA, representing mutated gene sequences that are found in multiple patients (such as KRAS mutations). SLATE is being evaluated in combination with immune checkpoint blockade in the Phase 2 portion of its clinical study (NCT03953235). Along with the candidates developed to date, SLATE represents the potential to develop a suite of "off-the-shelf” product candidates that target tumor-specific mutations across a number of patient populations and cancer types.
Gritstone Forward-Looking Statements
This press release contains forward-looking statements, including, but not limited to, statements related to the potential of Gritstone’s therapeutic programs; the advancements in Gritstone’s ongoing clinical trials; the timing of data announcements related to ongoing clinical trials and the initiation of future clinical trials. Such forward-looking statements involve substantial risks and uncertainties that could cause Gritstone’s research and clinical development programs, future results, performance or achievements to differ significantly from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the uncertainties inherent in the drug development process, including Gritstone’s programs’ early stage of development, the process of designing and conducting preclinical and clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, Gritstone’s ability to successfully establish, protect and defend its intellectual property and other matters that could affect the sufficiency of existing cash to fund operations. Gritstone undertakes no obligation to update or revise any forward-looking statements. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to the business of Gritstone in general, see Gritstone’s most recent Annual Report on Form 10-K filed on
Director, Investor Relations & Corporate Communications